As a career coach, I help a lot of job seekers find new employment or find meaning in their work. Here is my no.1 piece of advice -
If you are first starting out to look for another job... understand that you and employers are at the opposite ends of the spectrum when it comes to managing risk.
You are trying to ensure you apply for enough jobs that you will be getting more than one job offer so you can get the best job you can. Whilst they are trying to ensure that they get the right person for the job because mistakes are expensive for them.
Employees will go to job boards and apply for anything that fits their criteria. Employers on the other hand, will prefer to employ someone they know already if they can. More often than not, employers will either ask people who they know that might be looking to move (and even if they have to advertise will encourage them to apply) or make the job a temporary one to try out a prospect.
So how do you bring yourself closer to the way employers approach finding excellent employees? Think like them.
As well as applying through job boards, reconnect with your network to let people know you are ready to move and what sort of role you are looking for... (of course return the favour when you can) and consider taking up temporary or contract work. The added benefit of doing temporary work is that you will get a look inside many different companies and see who they are warts and all.
Good luck with your job search!